Research publications

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TICK-VIRUS-HOST INTERACTIONS/INTERFACE/DETERMINANTS DURING ARBOVIRAL TRANSMISSION

1. Development of a Small Animal Model for Deer Tick Virus Pathogenesis Mimicking Human Clinical Outcome. PLoS Negl Trop Dis. 2020 Jun 15;14(6):e0008359. doi: 10.1371/journal.pntd.0008359.
2. Utilization of RNA in situ Hybridization to Understand the Cellular Localization of Powassan Virus RNA at the Tick-Virus-Host Interface. Front Cell Infect Microbiol. 2020 Apr 28;10:172. doi: 10.3389/fcimb.2020.00172
3. Tick-Borne Encephalitis Virus Infection Alters the Sialome of Ixodes ricinus Ticks During the Earliest Stages of Feeding. Front Cell Infect Microbiol. 2020 Feb 18;10:41. doi: 10.3389/fcimb.2020.00041.
4. Ixodes scapularis salivary gland microRNAs are differentially expressed during Powassan virus transmission. Nature Sci Rep. Hermance et al., 2019.
5. Tick-Virus-Host Interactions at the Cutaneous Interface: The Nidus of Flavivirus Transmission. Viruses. Hermance et al 2018.
6. Generation of a Lineage II Powassan Virus (Deer Tick Virus) cDNA Clone: Assessment of Flaviviral Genetic Determinants of Tick and Mosquito Vector Competence. Vector Borne Zoonotic Dis. Kenney et al 2018. 
7. Powassan virus: An emerging arbovirus of public health concern in North America. Vector Borne Zoonotic Dis. Hermance and Thangamani 2017.
8. Transcriptional Immunoprofiling at the Tick-Virus-Host Interface during Early Stages of Tick-Borne Encephalitis Virus Transmission. Front. Cell. Infect. Microbiol. Thangamani et al 2017.
9. Tick-borne viruses and biological processes at the tick-host-virus interface. Frontiers in Microbiology. Front Cell Infect Microbiol. Kazimirova et al 2017. 
10. Concurrent micro-RNA mediated silencing of tick-borne flavivirus replication in tick vector and in the brain of vertebrate host. Sci Rep. Tsetsarkin et al 2016.
11. Immune Cell Targets of Infection at the Tick-Skin Interface during Powassan Virus Transmission. PLoS One. Hermance et al 2016. 
12. Ixodes scapularis saliva enhances Powassan virus transmission to the host, influencing its dissemination and the course of disease. Journal of Virology. Hermance and Thangamani 2016.
13. Proinflammatory cytokines and chemokines at the skin interface during Powassan virus transmission. J Invest Dermatol. Hermance and Thangamani 2017.
14. Host immune response to Dermacentor andersonii feeding. Front Microbiol.  Heinze et al 2014.
15. Early immunologic events at the tick-host interface. PLoS One. Heinze et al 2012.
16. Transcriptional profiling of the murine cutaneous response during initial and subsequent infestations with Ixodes scapularis nymphs. Heinze et al 2011. 
17. Blood feeding by the Rocky Mountain spotted fever vector, Dermacentor andersoni, induces interleukin-4 expression by cognate antigen responding CD4+T cells. Parasites & Vectors Thangamani & Boppan a et al 2009.
18. Differential expression of the salivary transcriptome of Aedes aegypti upon blood feeding. Parasites & Vectors. Thangamani and Wikel, 2009.
19. SAAG-4 is a Novel Mosquito Salivary Protein that Programs Host CD4+ T Cells to Express IL-4. Parasite Immunol. Thangamani & Boppana et al 2009. 

MOSQUITO-VIRUS-HOST INTERACTIONS/INTERFACE/DETERMINANTS DURING ARBOVIRAL TRANSMISSION

1. Measuring Alphavirus Fidelity Using Non-Infectious Virus Particles. Viruses. 2020 May 15;12(5):E546. doi: 10.3390/v12050546.
2. Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts. PLoS Pathog. Warmbrod et al 2019.
3. Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes. PLoS Negl Trop Dis. Saldaña 2017
4. Discovery of mosquito saliva microRNAs during CHIKV infection. Maharaj et al 2015. 
5. Host immune response to mosquito-transmitted chikungunya virus differs from that elicited by needle inoculated virus. PLoS ONE. Thangamani et al 2015. 

BIOLOGY OF DISEASE TRANSMISSION

1. Heartland virus infection in hamsters deficient in type I interferon signaling: protracted disease course ameliorated by favipiravir. Virology. Westover et al 2017.
2. An Overview of Animal Models for Arthropod-Borne Viruses. Comp Med. Reynolds et al 2017. 
3. Spinal Cord Ventral Horns and Lymphoid Organ Involvement in Powassan Virus Infection in a Mouse Model. Viruses. Santis et ak, 2016. 

VECTOR COMPETENCY / CAPACITY TO TRANSMIT ARBOVIRUSES

1. Insect-specific viruses detected in laboratory mosquito colonies: Implications for evaluating vector competence experiments. Am J Trop Med Hyg. Bolling et al 2015. 
2. Establishing Protocols for tick containment at Biosafety level 4. Pathog Dis. Thangamani and Bente, 2014. 
3. Experimental transmission of Mayaro virus by Aedes aegypti. Am J Trop Med Hyg. Long et al 2011. 
4. Influence of laboratory animal hosts on the life cycle of Hyalomma marginatum and implications for an in vivo transmission model for Crimean-Congo hemorrhagic fever virus. Front Cell Infect Microbiol. Gargili et al. 
5. Vertical transmission of Zika virus in Aedes aegypti mosquitoes. Am J Trop Med Hyg. Thangamani et al 2016.
6. Experimental infection with and maintenance of cell fusing agent virus in Aedes aegypti. AJTMH. Contreras et al 2017.
7. Culex quinquefasciatus and Aedes taeniorhynchus from the Gulf Coast are Refractory to Zika Virus Infection. Emerg Infect Dis. Hart et al, 2017.

TICK/INVERTEBRATE IMMUNITY

1. Molecular cloning, structure and bait region splice variants of alpha-2-macroglobulin from the soft tick Ornithodoros moubata. Insect Biochem Mol Biol. Saravanan (Thangamani) et al 2003 
2. Characterization of an alphamacroglobulin-like glycoprotein isolated from the plasma of the soft tick Ornithodoros moubata. Eur J Biochem. Kopacek et al 2000.
3. Structural Basis for a dual inhibition mechanism of a non classical kazal type inhibitor to regulate host and pathogen protease interactions. PLoS ONE  Tulsidas et al, 2011.
4. Modifying the substrate specificity of Carcinocscorpious rotundicauda serine protease inhibitor domain1 to target Thrombin. PLoS ONE. Tulsidas et al, 2010.
5. A novel serine protease inhibitor acts as an immunomodulatory switch while maintaining homeostasis. J Innate Immun. Thangamani & Jiang et al 2009.
6. Crystallization of a non-classical Kazal-type Carcinoscorpius rotundicauda serine protease inhibitor, CrSPI-1, complexed with subtilisin. Acta Cryst. Tulsidas et al, 2009. 
7. Spatial and temporal coordination of expression of immune response genes during Pseudomonas infection of horseshoe crab, Carcinoscorpius rotundicauda. Genes Immun Ding et al, 2005. 
8. The ancient origin of the complement system. EMBO J. Zhu et al , 2005.

ECOLOGY OF TICK AND TICK-BORNE DISEASES

1. Detection of Rickettsiae, Borreliae, and Ehrlichiae in Ticks Collected from Walker County, Texas, 2017-2018. Insects. Mendell et al, 2019.
2. Meeting the challenge of tick-borne disease control: A proposal for 1000 Ixodes genomes. Ticks Tick Borne Dis. Murgia et al 2019.

VECTOR CONTROL

1. Expression of a Synthetic Gene for the Major Cytotoxin (Cyt1Aa) of Bacillus thuringiensis subsp. israelensis in the Chloroplast of Wild-Type Chlamydomonas. Biology (Basel). Kang et al 2018.
2. Toward mosquito control with a green alga: Expression of Cry toxins of Bacillus thuringiensis subsp. israelensis (Bti) in the chloroplast of Chlamydomonas. Journal of applied Phycology. Kang et al 2017.